Compared with non-CIN group patients, CIN group patients had a higher level of GDF-15 and baseline serum creatinine concentration (1232 ± 366.6 ng/L vs. 939.2 ± 309.6 ng/L, 108.2 ± 34.1 ng/L vs. 72.6 ± 16.6 ng/L, all P <0.001) and a lower level of eGFR (56.6 ± 24.0 ml/min/1.73m2 vs 88.7 ± 22.3mL/min/1.73m2, P <0.001). The gene discussed is GDF15; the disease is cervical squamous intraepithelial neoplasia.