As showed in Fig 2, multivariate logistic model indicated that the highest quartiles (Q4) was significantly associated with an increased risk of CIN compared with lower level of GDF-15 (Q1, Q2 and Q3) (OR : 3.572, 95%CI: 1.803–7.078, P <0.001). This evidence concerns the gene GDF15 and cervical squamous intraepithelial neoplasia.