This included aluminum hydroxide, a known activator of the inflammasome that has a long track record of safety in human pediatric vaccines [26], or chemically-detoxified Re LPS from Salmonella Minnesota (MPL), a TLR4 agonist that is used as part of the adjuvant formulation in several licensed adult vaccines [27] as well as for 6 to 12-week old children receiving the RTS,S malaria vaccine [28]. The gene discussed is TLR4; the disease is malaria.