References supporting the efficacy of a higher dose range (20 mg/kg, above the currently recommended 15 mg/kg) were not found in the literature, and, owing to the associated risk of adverse events when combined with other CYP3A4 inhibitors (discussed below), there is no current evidence base to suggest that a higher dose of ciprofloxacin than currently recommended is warranted in shigellosis. Here, CYP3A4 is linked to shigellosis.