Increasing evidence indicated that LACTB was a novel protease homologues involved in energy homeostasis and could regulate the metabolic circuitry.15, 16, 17 In addition, dysregulated LACTB was associated with obese phenotype and atherosclerosis, which indicated the role of LACTB in fat metabolism disorder.18 Moreover, metabolic reprogramming is a cancer hallmark and abnormal fatty acid metabolism is related to the cancer progression, suggesting key enzymes of fatty acid metabolism may be served as a novel therapeutic target in cancers. The gene discussed is LACTB; the disease is cancer.