In addition, LACTB was substantially downregulated and correlated with a poor outcome of glioma patients.7 Overexpression of LACTB could inhibit the proliferation, invasion, and angiogenesis of glioma cells by regulating expression of PCNA, MMP2, MMP9, and VEGF.7 All these results indicated LACTB was a bona fide new tumor suppressor.6, 8 However, the relationship between LACTB expression and prognosis in BRCA, as well as the regulatory network of LACTB remain largely unclear. This evidence concerns the gene MMP9 and central nervous system cancer.