In addition, we carried out in vitro experiments and also found that DGCR5 inhibited cell proliferation, migration, and invasion with no obvious effects on cell apoptosis of A549 cells, in vivo assay further confirm a tumor suppressor role for DGCR5 in LC evidenced by elevation of DGCR5 greatly reduced tumor size/weight and Ki67 protein expression in comparison with A549‐control group. Here, DGCR5 is linked to neoplasm.