Downregulation of DGCR5 in tissues and serum was correlated with poor prognosis of hepatocellular carcinoma17; reciprocal regulation of DGCR5 and miR‐320a influenced pancreatic ductal adenocarcinoma cellular malignant phenotype.18 Therefore, this study aimed to investigate the function of DGCR5 in LC and identify the miRNAs that could be targeted by DGCR5 as well as the target genes that could be targeted by miRNAs, eventually providing a novel therapeutic target for LC. This evidence concerns the gene DGCR5 and laryngotracheoesophageal cleft.