It is well known that PPARγ and PPARα are both transcriptional regulators of adrp/plin2 and fsp27/cidec45 and that the overexpression of fsp27/cidec and adrp/plin2 prevents the access of lipases to the core of the lipid droplet, thus impairing the hydrolysis of TG.46, 47 Therefore, the increased expression of lipid droplet proteins may be a relevant pathogenic factor for hepatic steatosis,48 contributing to the accumulation of lipids in P465L mice. The gene discussed is PPARA; the disease is Hepatic steatosis.