INS and Insulin resistance: Both on a chow diet or after a short challenge with an HFD, P465L mice were normoglycaemic in the presence of hyperinsulinaemia (Figure 1A), suggesting that their insulin secretion was able to compensate for their peripheral insulin resistance; moreover, when challenged with an HFD for a period of 12 weeks, P465L mice became hyperglycaemic (Figure S1).