The independent predictors for recurrence were tumor size greater than 4 cm (HR 2.5; 95% CI 1.14–5.40), Ki67 > 5% (HR 3.0; 95% CI 1.34–6.81), and lymph node metastases (HR 3.3; 95% CI 1.40–7.70) (Table 1). Here, MKI67 is linked to neoplasm.