CASP8 and acute myeloid leukemia: AML is a type of leukemia that shows abnormal expression of splicing factors [54]. CASP8 plays a central role in programmed cell death as a proapoptotic protease, and CASP8L is the main variant in human peripheral blood lymphocytes [55]. CASP8L exhibits antiapoptotic functions, and its expression is increased CD34+ stem cells of patients with AML-M0 [56].