MAPT and early-onset autosomal dominant Alzheimer disease: Adult-specific exon 10 of the tau gene encodes the microtube binding domain of the tau protein, and SRSF4 regulates exon 10, resulting in increased expression of the abnormal tau isoform FTDD-17, which can lead to neurodegenerative diseases called tauopathies (including Alzheimer's disease, FTDD-17, trisomy 21, and diabetic muscle infarction) [32].