Due to the important role of VCAM-1 in migration of BMMSCs and the critical role of BMMSCs migration to site of bone formation prior to their osteogenic commitment for new bone formation during physiological bone remodelling and bone fracture healing, the findings in the current study indicated the important role of miR-142-5p in osteoporosis development involving targeting VCAM-1 and inhibiting BMMSC migration. This evidence concerns the gene VCAM1 and osteoporosis.