CRP and cancer: Physical activity is linked to increased functional capacity, improved mood, increased immune function, decreased fatigue, improved health perceptions, and improved HRQoL.4,5 From a psychosocial perspective, participating in physical activity provides a positive feedback loop as the cancer survivor sees his/her body respond and engage successfully in exercise.6 From a biological perspective, exercise has been suggested to reduce stress and chronic inflammation.7 Stress and chronic inflammation are indicated by high levels of cortisol and c-reactive protein (CRP), respectively.