CRP and cancer: In addition to examining the potential for improving HRQoL and perceived barriers with exercise among cancer survivors, this study also contributes new insight into how the anti-inflammatory effects of exercise and reduction of CRP may be mediated by body composition and TST.5 The intervention appeared to have the greatest impact on reducing CRP levels among participants that had most recently completed treatment, which underscores the greater opportunity for improvement with earlier intervention post-treatment.