The top five upregulated lncRNAs in HCC (Supplimentery Table 2) were: lnc-CCDC167-2 (1 million-fold), lnc-TPTE-3 (18378-fold), lnc-C21orf67-10 (9271-fold), lnc-TMEM8A-1 (6308-fold), and lnc-CRK-3 (3027-fold), with downregulation seen in: lnc-SNHG6:15 (99-fold), HSD17B10-3 (65-fold), lnc-CCNB1IP1-1 (50-fold), GAS5 (45-fold, multiple transcripts), and lnc-ARHGEF6-4 (28-fold). The gene discussed is ARHGEF6; the disease is hepatocellular carcinoma.