Indeed, mutations in several RBPs including Transactive-response DNA-binding Protein, 43 kDa (TDP-43), Fused in Sarcoma (FUS) and TATA-Box Binding Protein Associated Factor 15 (TAF15) have been causally linked to familial form of ALS leading to RNA processing defects in mouse models17,18. The gene discussed is FUS; the disease is amyotrophic lateral sclerosis.