However, when FoxM1 was reconstituted in IPF fibroblasts overexpressing FoxO3a, γH2AX expression was decreased compared to FoxO3a overexpression alone, with RAD51 and BRCA2 expression restored to levels similar to those following FoxM1 overexpression alone. The gene discussed is FOXO3; the disease is idiopathic pulmonary fibrosis.