To further support that FoxO3a modulates this pathway, FoxM1, RAD51, and BRCA2 mRNA expression levels were also significantly reduced following radiation in FoxO3a overexpressing IPF fibroblasts compared to IPF fibroblasts overexpressing GFP (Fig. 7b–d). This evidence concerns the gene FOXO3 and idiopathic pulmonary fibrosis.