ALKBH5 and glioblastoma: A recent study revealed that overexpression of ALKBH5 is required for the proliferation and tumorigenesis of glioblastoma stem cells and predicts poor patient survival.97 Additionally, knockdown of ALKBH5 expression in MDA-MB-231 human breast cancer cells significantly reduced their capacity for tumor initiation attributing to the reduced of breast cancer stem cells.98