FTO and acute myeloid leukemia: 92 Notably, specific m6A sites in FTO target mRNA transcripts such as ASB2, RARA and MYC have been demonstrated with quantitative methods (i.e., luciferase reporter/mutagenesis assays and gene region-speific m6A qPCR) to be regulated by FTO.91,92 The possible mechanisms underlying the phenomenon that both FTO and METTL14 play oncogenic roles in AML have been discussed.77,93