METTL3 and acute myeloid leukemia: Similar to zebrafish embryos depleted of METTL3, zebrafish embryos lacking WTAP undergo increased apoptosis.13 WTAP has been reported to be upregulated in > 30% AML cases and paly an oncogenic role in AML.41 Although it has not yet been investigated whether m6A is involved in the role of WTAP in AML, METTL14 expression was found to be increased in AML,77 implying that regulation of m6A levels by the m6A writer complex may be a key factor in AML oncogenesis.