EGFR and non-small cell lung carcinoma: NSCLC patients with EGFR mutations are responsive to first-generation EGFR inhibitors such as gefitinib and erlotinib, which have been approved by FDA as the first-line NSCLC therapies, resulting in longer median survival up to 24–30 months than those observed in patients with wild-type (WT) EGFR8.