Besides, CDK4/E2F1 signal is regulated by MALAT120 in breast cancer, p21 expression is repressed by oncogenic lncRNA FAL1 in ovarian cancer30 and p16 (INK4A) expression is regulated by lncRNA MIR31HG to modulate senescence in melanoma31. The gene discussed is CDKN2A; the disease is breast carcinoma.