NKD1 and pancreatic ductal adenocarcinoma: Knockout of FZD5 robustly inhibited cell growth in human Ring finger protein 43 (RNF43)-mutant pancreatic ductal adenocarcinoma cells (PDAC) in clonogenic growth assays, and editing of FZD5 significantly inhibited the expression of WNT target genes AXIN2 and NKD1(Naked cuticle homolog 1) [36].