DKK1 and Wilms tumor: Moreover, the exogenous expression of two kinds of WNT antagonists, sFRP1 (secreted Frizzled-related protein 1) and DKK1 (Dickkopf WNT signaling pathway inhibitor 1), could promote the sensitivity of Wilms’ tumor cells to the antibody treatment, indicating that a combination of anti-FZDs antibodies and WNT inhibitors may greatly benefit cancer therapy [87].