SFRP5 and obesity due to melanocortin 4 receptor deficiency: This finding was supported by a study that identified that low serum levels of SFRP5 played a contributory factor in the pathophysiology of obesity and T2DM, while suggesting that HOMA-IR, BMI, and triglycerides were independent, related factors capable of influencing the plasma levels of SFRP5 [58].