UNC13C and developmental and/or epileptic encephalopathy with spike-wave activation in sleep: Out of the 30 rare CNVs identified in patients with RE by Dimassi, only two overlap with our larger cohort; we both identified one patient with a maternally inherited deletion of part of UNC13C, and we identified a de novo deletion of the 16p13.11 hotspot, whereas Dimassi identified a maternally inherited duplication of the same region.26 A heterogeneous mixture of CNVs has also been identified in a cohort of patients with LKS and CSWS17, which form the severe end of the epilepsy-aphasia spectrum, with RE at the mild end.