CKD patients with diabetes mellitus showed lower HDL-C levels (P < 0.001), increased SAA (P = 0.045), lower arylesterase activity of paraoxonase (P = 0.013), and HDL associated Lp-PLA2 activity (P = 0.010) whereas antioxidative activity was not different (P = 0.935). The gene discussed is PLA2G7; the disease is diabetes mellitus.