CHCHD10 and amyotrophic lateral sclerosis: We discovered a novel CHCHD10 mutation (Q108P) in a highly conserved residue within the coiled‐coil‐helix‐coiled‐coil‐helix (CHCH) domain in a young ALS patient with aggressive disease progression and analyzed its pathogenicity in transfected heterologous cells and primary rat neurons.