For example, previous translational data have suggested the involvement of the hemochromatosis gene (HFE) [18] and UGT1A1 [19] polymorphisms in hepatic enzyme elevation with pazopanib and vascular endothelial growth factor (VEGF) polymorphisms [20] with hypertension effects of sunitinib. The gene discussed is VEGFA; the disease is hemochromatosis type 1.