Among Asian patients, the most common treatment-emergent AEs (> 40% in either treatment arm) were hypertension, diarrhea, palmar-plantar erythrodysesthesia syndrome (PPE), fatigue, thrombocytopenia/platelet count decreased, neutropenia/neutrophil count decreased, leukopenia/WBC count decreased, anemia/hemoglobin decreased, ALT increased, AST increased, and decreased appetite. The gene discussed is GPT; the disease is hypertensive disorder.