For example, previous translational data have suggested the involvement of the hemochromatosis gene (HFE) [18] and UGT1A1 [19] polymorphisms in hepatic enzyme elevation with pazopanib and vascular endothelial growth factor (VEGF) polymorphisms [20] with hypertension effects of sunitinib. This evidence concerns the gene UGT1A1 and hemochromatosis type 1.