SLC5A2 and endothelial dysfunction: Such improvement might also be attributed to the simultaneous effects of decreased BP [41], reduced body weight, less visceral fat [42, 43], and improvements in endothelial dysfunction [44, 45], systemic micro-inflammation [43], cardiac injury [46], left ventricular hypertrophy, etc. Further investigation is needed to elucidate the mechanism for the improved left ventricular diastolic function resulting from the administration of an SGLT2 inhibitor.