Bacterial load in non-CF bronchiectasis has been correlated with increases in airway (NE, IL-8, IL-1β and TNF-α) and systemic (ICAM-1, E-selectin) derived inflammatory markers, phenomena confirmed in vitro using bronchial epithelial cell lines treated with sputum from bronchiectasis patients [103, 104]. The gene discussed is SELE; the disease is bronchiectasis.