ELANE and bronchiectasis: Antibacterial neutrophil responses (such as reactive oxygen species (ROS) formation) are activated through the IL-8-CXCR1 axis, but proteolytic cleavage mediated by neutrophil elastase (NE), which itself is associated with exacerbations and lung function decline in bronchiectasis, impairs antibacterial neutrophil functions [69, 70].