TLR2 and tuberculosis: Secondly, on Ingenuity Pathway Analysis (IPA) of gene to gene relationships, it is described that focus genes such as the Toll Like Receptor-2 (TLR2), Interleukin12 (IL12), and Interferon-gamma (IFNG) all play important roles in the innate and adaptive immune response and where genetic polymorphisms are present leads to an increased risk of both TB and NTM infection [29].