For example, at least three genes with PUF60-sensitive exons were associated with mental retardation, including EDC3, EPS15L1 and TUSC3. The MIR-derived, penultimate exon in TUSC3 contains a canonical stop codon that terminates translation of a longer TUSC3 isoform, which has a distinct C-terminus (Supplementary Figure S8A). This evidence concerns the gene PUF60 and Intellectual disability.