The top 25 significantly different pathways were selected (Fig 4A), including pathways in cancer, the PI3K-Akt signaling pathway, Rap1 signaling pathway, TNF signaling pathway, focal adhesion, and some disease pathways such as rheumatoid arthritis, tuberculosis, Influenza A, and Toxoplasmosis. This evidence concerns the gene AKT1 and rheumatoid arthritis.