The observed astrogliosis and microgliosis in different brain regions of TAR6/6 mice provides evidence for a similar neuroinflammatory pathology compared to another TDP-43 transgenic mouse [30], the SOD1 mouse model [31], human ALS cases [32] or human FTLD with mutated progranulin [33]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.