Microarray-based expression profiling of 104 resected human cholangiocarcinomas [23] revealed reduced expression of GABRB3, PANK1, and LRRC8A, but not GABRA5 or ADO, compared to micro-dissected bile duct controls (Fig 6B, Figure A in S5 Fig). This evidence concerns the gene GABRB3 and cholangiocarcinoma.