Stratifying the cohort of 104 cholangiocarcinomas for RNA expression above and below the mean revealed that low RNA expression of GABRA5, LRRC8a, ADO and PANK1, but not GABRB3 (Figure B in S5 Fig), was associated with reduction of the median survival time of patients by 1.8, 2.1, 3.3, and 4.3 years, respectively (Fig 6C). This evidence concerns the gene GABRB3 and cholangiocarcinoma.