ETV5 and central nervous system cancer: Fig 3 and S1 Fig show the comparison of using betweenness and closeness to differentiate the tumor and normal networks. The betweenness metric identifies genes that are substantially different across the two networks; the closeness metric does not identify any such stand-out genes. It should be noted that Etv5 was not among the 50 most differentially-expressed genes by standard differential expression analysis, and it is unlikely that it would have been identified as a potential glioma network regulator.