KIT and colorectal carcinoma: Our previous results showed that azoxymethane (AOM) and dextran sodium sulfate (DSS) induced MCA that occurred in wild-type (WT) mice at week 37, while c-kit loss-of-function mutant mice (Wadsm/m) only developed regular CRC (non-MCA) [15], preliminarily indicating that c-KIT signaling played a key role in the development of MCA.