HIF1A and cancer: Choi et al. [43] identified a compound, diacetoxyscirpenol (DAS) (No. 22) (Figure 5), which originated from a marine bacterium living on red alga, contained the 12, 13-epoxytrichothecene group of sesquiterpenes as the core structure, and inhibited HIF-1 expression and its transcriptional activity in cancer cells exposed to hypoxia.