Examination of the KEGG pathway for NAFLD (hsa04932) demonstrated transcriptional dysregulation of mediators of insulin resistance (IRS2, P1K3R1, AKT1), steatohepatitis ( JUN, ERN1) and neutrophil infiltration and inflammation (CXCL8) (table 1). The gene discussed is IRS2; the disease is metabolic dysfunction-associated steatotic liver disease.