In the next step, AML patients based on DNMT3A and FLT3-ITD mutations were divided into four groups: group A (DNMT3A R882wt /FLT3-ITDneg), group B (DNMT3A R882mut /FLT3-ITDpos), group C (DNMT3A R882wt/FLT3-ITDpos), and group D (DNMT3A R882mut/FLT3-ITDneg). Here, DNMT3A is linked to acute myeloid leukemia.