The immunopeptidome, the collection of the peptides presented by human leucocyte antigens (HLA), the human MHC, comprises thousands of peptides derived from degradation of cellular proteins, and is a reflection of the protein expression repertoire of the cells.4, 5 Cancer cells, due to their aberrant expression of proteins that enable them to outgrow the normal tissue and to survive immune surveillance, are suggested to present a different set of peptides in comparison to normal tissues. This evidence concerns the gene HLA-C and cancer.