In the acute setting, higher values should be used (BNP <100 pg/mL, NTproBNP <300 pg/mL).6 In contrast, NICE suggests a BNP threshold of 100 pg/mL and an NTproBNP threshold of 400 pg/mL for referral of patients with suspected heart failure.5 The gene discussed is NPPB; the disease is heart failure.