In another experiment, T cells with two complementary CARs against GPC3 and asialoglycoprotein receptor 1 (ASGR1) decreased the risk of on-target, off-tumor toxicities and demonstrated potent antitumor immune responses targeting GPC3+ ASGR1+ HCCs both in vivo and in vitro [41]. This evidence concerns the gene ASGR1 and neoplasm.