The other way round, excessive stimulation of muscle autophagy, experimentally obtained by the overexpression of TP53INP2/DOR, exacerbated muscle atrophy in tumor-bearing mice (unpublished data), while activation of autophagy by means of the mTOR inhibitor rapamycin was shown to positively affect the skeletal muscle in the C26 hosts [16]. The gene discussed is TP53INP2; the disease is neoplasm.