The efficiency of the combined diagnosis in distinguishing HCC cases from healthy controls (AUC = 0.970, 95% CI = 0.949–0.991), from cases of cirrhosis (AUC = 0.743, 95% CI = 0.664–0.821), or from cases of hepatitis B (AUC = 0.877, 95% CI = 0.817–0.938) was higher when compared to that using plasma hsa_circ_0001445 levels or serum AFP levels alone (Table 3). This evidence concerns the gene AFP and Cirrhosis.