Some researches reported that IL-2, IL-12, IL-1α, IL-1β, IL-6, and TNF-α could induce acute phase reaction, stimulate the growth and differentiation of hematopoietic precursor cells, promote the proliferation of synovial fibroblasts, and cause joint damage [22] in the pathogenesis of RA. Here, IL1A is linked to rheumatoid arthritis.