As it is well known that in allergic patients there is an overproduction of Th2 cytokines, that can induce the isotopic switch of B cells toward IgE isotype immunoglobulins and recall on-site cells responsible for the allergic inflammation (mast cells and eosinophils), the authors concluded that there is no valid justification for the statement that allergic diseases decline in the elderly. This evidence concerns the gene IGHE and allergic disease.