In fact, PHB1 and PHB2 not only function in biological processes like cancer cell proliferation, metastasis and apoptosis in tumorigenesis and cancer development, but also play a role in modulating other processes such as cell differentiation in hepatocarcinoma, neuroblastoma and acute promyelocytic leukemia50, 100, 101 and mitophagy42. Here, PHB1 is linked to cancer.