As shown in Fig. 2, OB HF patients demonstrated lower levels of proteins associated with inflammatory status (Receptor for advanced glycosylation end products (RAGE), C-X-C motif chemokine 6 (CXCL6), C-X-C motif chemokine 1 (CXCL1), CD40L receptor (CD40) and NF-kappa-B essential modulator (NEMO) as compared to NOB HF patients. The gene discussed is CXCL1; the disease is hydrops fetalis.