APOE and endothelial dysfunction: Figure 5A, B concurs with a previous finding that incubation of Genipin decreases ACh-induced endothelium-dependent vasodilation in WT and ApoE KO-EX, but not in ApoE KO, which indicates that the increase in ROS by UCP-2 inhibition exacerbates endothelial dysfunction in mesenteric arteries of ApoE KO mice.