Furthermore, we showed that exercise training significantly reduced the elevated CHOP expression in the mesenteric arteries of ApoE KO mice (Fig. 4A, B), which aligns with the previous findings that regular exercise training decreased the expression of CHOP in myocardial infarction rats29 and CHOP-mediated apoptosis proteins, Bcl-2 & Bax in obese mice30. This evidence concerns the gene APOE and myocardial infarction.