Recently, Cheang et al. reported that treadmill exercise ameliorated endothelial dysfunction via the PPAR-δ dependent mechanism with a decrease in the expression of p-eIF2α, ATF3 & 4 and an increase in intracellular NO production in the aorta and mesentery artery of db/db mice16. The gene discussed is EIF2A; the disease is endothelial dysfunction.