Mice generated by this method have been compared to the 3xTg-AD line (Table 2), which is a transgenic mouse model that contains mutations in APP, PSEN1 and MAPT. Both models show altered expression levels of synaptic proteins, increased levels of hyperphosphorylated Tau in the brain, changes in insulin signaling, and neuroinflammation (Chen et al., 2012a). This evidence concerns the gene PSEN1 and Alzheimer disease.