The LSB staging model was simpler to use with higher prediction accuracy compared with the ESCC staging model comprising ubiquitin-conjugating enzyme E2 C (UBE2C) and matrix gla protein (MGP) gene expression levels [19] and TNM staging or the FENSAM (Fascin, Ezrin, N stage, surgery extent, activating transcription factor 3 [ATF3], M stage)staging model constructed in our previous study [16]. The gene discussed is FSCN1; the disease is esophageal squamous cell carcinoma.