Although AD GWAS genes were not specifically enriched in the pro- and anti-inflammatory DAM modules, several AD-associated genes were also identified in the anti-inflammatory Yellow module (Apoe, Hla-dqa1) as well as the pro-inflammatory Magenta module (Ms4a4e, Hla-dqb1 and Treml2) (Fig. 9c-d, Additional file 5: Table S5, Additional file 6: Table S6). This evidence concerns the gene MS4A4E and Alzheimer disease.