Unique splicing of Bin1 in microglia and oligodendroglia not seen in neurons or astrocytes has also been suggested [59, 67] and Bin1 has also been identified as a highly abundant microglial protein in a recent microglial proteome [68] although the exact role of Bin1 in homeostatic microglia and in AD pathogenesis remains unclear. Here, BIN1 is linked to Alzheimer disease.