Pathway analyses of key members of AD modules identified transcriptional regulators (Additional file 8: Figure S3, Additional file 3: Table S3) including RelA, Stat1, p53 and Nfkb1 for Magenta, Lxrα/β and Atf-1 for Yellow and Cebpα and Foxo3a for Blue modules. The gene discussed is FOXO3; the disease is Alzheimer disease.