By targeting decreased pro-inflammatory DAM and increased anti-inflammatory DAM as the desired effects of ideal immuno-modulatory strategies in AD, we used CMAP to identify and prioritize several classes of existing drugs that can be safely used in humans including statins, Syk inhibitors and norepinephrine reuptake inhibitors that are predicted to selectively inhibit pro-inflammatory DAM while promoting anti-inflammatory DAM. This evidence concerns the gene SYK and Alzheimer disease.