BRCA2 and neoplasm: As shown in Table 1, PARP1-positivity was significantly associated with sex of patients (P = 0.038), higher tumor stage (P = 0.024), higher histologic grade (P = 0.008), and the expression of γH2AX (P = 0.001), BRCA1 (P = 0.009), and BRCA2 (P = 0.001).