PCNA and neoplasm: We found that the tumor cells from the mice treated with EPI-MBs + mAb combined with UTMD significantly increased the staining of Caspase-3, Bax, and TUNEL, and remarkably decreased the staining of PCNA, Bcl-2, and CD31, compared to those in the tumor cells from the mice treated with EPI-MBs + mAb, or EPI, or PBS control (P < 0.05 or P < 0.01 or P < 0.005; Fig. 5b–d, f–h).