PCNA and neoplasm: We found that the characteristic apoptosis molecules, such as Caspase-3, Bax, and TUNEL, were significantly increased in the tumor tissues of mice treated with the combination of EPI-MBs + mAb plus UTMD, whereas the inhibition of apoptosis and proliferation as well as promotion of vascularization molecules (PCNA, Bcl-2, and CD31) were respectively decreased compared with any other groups.