Various studies showed that over expression of micro-RNA-497 can suppress cell proliferation and induces apoptosis through targeting paired box 3 [46], paired box 2 [52] and YAP1 [59], suppress EMT and metastasis by targeting fos related antigen-1 [48] or vascular endothelial growth factor-A [49], and reduce tumor growth and invasion by suppressing BDNF [47]. The gene discussed is BDNF; the disease is neoplasm.